XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 42.YMWUJEATGCHHMB-UHFFFAOYSA-N methylene dichloride Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 104.LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 140.239000003146 anticoagulant agent Substances 0.000 claims abstract description 5.238000005917 acylation reaction Methods 0.000 claims abstract description 5.238000004519 manufacturing process Methods 0.000 claims abstract description 8.125000002496 methyl group Chemical group C()()* 0.000 claims abstract description 23.125000003118 aryl group Chemical group 0.000 claims abstract description 23.150000001875 compounds Chemical class 0.000 claims abstract description 26.238000006243 chemical reaction Methods 0.000 claims abstract description 31.-1 alkyl 4-(3-oxomorpholine-4- yl)phenylcarbamates Chemical class 0.000 claims abstract description 33.239000000126 substance Substances 0.000 claims abstract description 42.125000002924 primary amino group Chemical group N()* 0.000 claims abstract description 42.125000000325 methylidene group Chemical group C()=* 0.000 claims abstract description 86.
BRLQWZUYTZBJKN-VKHMYHEASA-N (+)-Epichlorohydrin Chemical compound BRLQWZUYTZBJKN-VKHMYHEASA-N 0.000 title claims abstract description 11.238000002360 preparation method Methods 0.000 title claims abstract description 57.
Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority claimed from CZPV2012-111 external-priority Application filed by Zentiva, K.S. Priority date (The priority date is an assumption and is not a legal conclusion. Inventor Ales Halama Radim Krulis Ondrej Dammer Stanislav KALASEK Original Assignee Zentiva, K.S. Google Patents WO2013120465A1 - A process for the preparation of rivaroxaban based on the use of (s)-epichlorohydrin WO2013120465A1 - A process for the preparation of rivaroxaban based on the use of (s)-epichlorohydrin
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